What is MOTS-c?
Updated October 2026
MOTS-c is one of a small class of mitochondrial-derived peptides — encoded not in the nucleus but in the mitochondrial genome itself.
What makes it unusual
MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a short peptide encoded within mitochondrial DNA rather than the nuclear genome. This makes it a notable subject in cellular-metabolism and longevity research.
Research directions
- AMPK metabolic-pathway signaling in cell models
- Glucose-handling and metabolic-stress research
- Mitochondrial-biology studies
Compliance
Lyophilized, third-party tested, in-vitro research use only.